The New Jersey Center for Biomaterials (NJCBM) uses advances of 3D bioprinting and additive manufacturing to develop advanced biomedical products for tissue engineering and regenerative medicine, and for drug delivery purposes. We also use the 3D printers to fabricate unique tools for culturing cells and for fabricating custom-designed surgical tools. Computer Aided Tissue Engineering from 3D CAD models are used to create physical 3D scaffolds to produce custom devices to test interaction of cells with biopolymers and implants for pre-clinical applications in animals. Our capabilities include filament-fed 3D printers (a single head printer (Type A machine) and a dual head printer (Monoprice)), pressure assisted printers (solvent-cast printer (BioBots), several bioprinters for educational purposes (SE3D)), stereolithographic equipment using UV curable resins for making 3D molds (Formlabs), and state-of-the-art EnvisionTec’s 3D Bioplotter System (Manufacturer series BIO-01-1000). EnvisionTec Bioplotter is the most powerful 3D printer at our center that can print polymer powders, filaments, or hydrogels. A built-in camera for needle calibration ensures consistent prints. It lets us achieve printing of a wide range of polymers including center`s proprietary formulations especially those that need high temperature and high pressure to get a fine (~100mm) filament. EnvisionTec 3D Bioplotter also offers handling of multiple materials through five print heads including polymers and hydrogels within the same structure with extreme accuracy. All of our printers enable us to produce implant prototypes faster, reproducibly, and in custom shapes that are not possible to obtain with any other techniques.