Cell material interactions

Chemists, material scientists and biologists work very closely at NJCBM to develop new biomaterials.  New polymers are synthesized by chemists and then are fabricated into various material forms such as films, fibers, fiber mats and scaffolds.  A team of biologists works together to understand the interaction between cell and new materials and identify potential applications for these materials.  Our discovery of the cellular responses to materials helps the chemist and material scientist to improve the design of novel materials.  In addition, through the understanding of the cell-material interaction, we also introduce biological activity to synthetic polymer constructs to generate bioactive scaffolds such as decellularized extracellular matrix (ECM) decorated scaffolds, hierarchy scaffold with signaling molecules (growth factors, peptides, epigenetic drugs) in gradient distribution.  Our areas of interest and capabilities include:

  1. Biocompatibility evaluation (In vitro cytotoxicity assay ISO 10993-5 and compatibility assays adapted to various specific cell types and materials)
  2. Cellular behaviors on new materials: adhesion, proliferation, migration, gene expression, ECM deposition and functionality of primary cells
  3. Cell interaction with ECM derived from various primary cells
  4. Material-guided mesenchymal stem cell differentiation
  5. Inflammatory responses to materials in vitro
  6. Cell-material interaction via exosomes and epigenetic factors
  7. Infection resistance of synthetic and biological materials
  8. Myelination of Schwann cells in an in vitro model

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Scale bar=10 μm

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Chondrocyte pellets

Collagen I- red

Collagen II-green

Nuclei-blue